Assessment of acrosome and nuclear abnormalities in human spermatozoa with large vacuoles
نویسندگان
چکیده
منابع مشابه
Assessment of acrosome and nuclear abnormalities in human spermatozoa with large vacuoles.
BACKGROUND Spermatozoa with large vacuoles (SLV) may have a negative impact on embryo development. The origin of these vacuoles is unknown. We evaluated acrosome and nucleus alterations in isolated SLV, versus unselected spermatozoa. METHODS We studied 20 patients with teratozoospermia. Spermatozoa from the native semen sample and spermatozoa presenting a vacuole occupying >13.0% total head a...
متن کاملSignificance of large nuclear vacuoles in human spermatozoa: implications for ICSI.
The aim of this study was to determine the extent of DNA fragmentation and the presence of denatured single-stranded or normal double-stranded DNA in spermatozoa with large nuclear vacuoles (LNV) selected by high magnification. Fresh semen samples from 30 patients were prepared by discontinuous isolate concentration gradient. Spermatozoa with normal nucleus (NN) and LNV were selected at x8400 m...
متن کاملlarge nuclear vacuoles in spermatozoa negatively affect pregnancy rate in ivf cycles
background: recently, motile sperm organelle morphology examination (msome) criteria as a new real time tool for evaluation of spermatozoa in intracytoplasmic sperm injection (icsi) cycles has been considered. objective: the aim was to investigate the predictive value of msome in in vitro fertilization (ivf) in comparison to icsi cycles and evaluation of the association between msome parameters...
متن کاملLarge nuclear vacuoles in spermatozoa negatively affect pregnancy rate in IVF cycles
BACKGROUND Recently, motile sperm organelle morphology examination (MSOME) criteria as a new real time tool for evaluation of spermatozoa in intracytoplasmic sperm injection (ICSI) cycles has been considered. OBJECTIVE The aim was to investigate the predictive value of MSOME in in vitro fertilization (IVF) in comparison to ICSI cycles and evaluation of the association between MSOME parameters...
متن کاملLarge human sperm vacuoles observed in motile spermatozoa under high magnification: nuclear thumbprints linked to failure of chromatin condensation.
BACKGROUND An embryo's ability to grow and implant can be improved by selection of a normal spermatozoon with a vacuole-free head. However, large vacuoles in spermatozoa have yet to be fully characterized. The present study aimed to determine whether these vacuoles are of nuclear, membrane and/or acrosomal origin. METHODS We studied 15 infertile patients with differing sperm profiles. For eac...
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ژورنال
عنوان ژورنال: Human Reproduction
سال: 2010
ISSN: 0268-1161,1460-2350
DOI: 10.1093/humrep/deq297